تری فلورو استیک اسید,Trifluoroacetic acid

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Revision Date 04.05.2020                    Version 11.13

SECTION 1. Identification of the substance/mixture and of the company/undertaking 1.1 Product identifier

Catalogue No.

808260

Product name

Trifluoroacetic acid for synthesis

REACH Registration Number

A registration number is not available for this substance as the substance or its use are exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No.

76-05-1

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses

Chemical for synthesis

For additional information on uses please refer to the Merck

Chemicals portal (www.merckgroup.com).

1.3 Details of the supplier of the safety data sheet

Company

Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0

Responsible Department

LS-QHC * e-mail: prodsafe@merckgroup.com

1.4 Emergency telephone

number

Please contact the regional company representation in your country.

SECTION 2. Hazards identification

2.1 Classification of the substance or mixture Classification (REGULATION (EC) No 1272/2008)

Acute toxicity, Category 4, Inhalation, H332

Skin corrosion, Category 1A, H314

Long-term (chronic) aquatic hazard, Category 3, H412

For the full text of the H-Statements mentioned in this Section, see Section 16.

Page 1 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

2.2 Label elements

Labelling (REGULATION (EC) No 1272/2008)

Hazard pictograms

Signal word

Danger

Hazard statements

H314 Causes severe skin burns and eye damage.

H332 Harmful if inhaled.

H412 Harmful to aquatic life with long lasting effects.

Precautionary statements

Prevention

P273 Avoid release to the environment.

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

Response

P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.

Remove contact lenses, if present and easy to do. Continue rinsing.

P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

Reduced labelling (≤125 ml)

Hazard pictograms

Signal word

Danger

Hazard statements

H314 Causes severe skin burns and eye damage.

H412 Harmful to aquatic life with long lasting effects.

Precautionary statements

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

index -No.            607-091-00-1

2.3 Other hazards

None known.

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The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

SECTION 3. Composition/information on ingredients 3.1 Substance

Formula

CF₃COOH

C₂HF₃O₂ (Hill)

index -No.

607-091-00-1

EC-No.

200-929-3

Molar mass

114,02 g/mol

Hazardous components (REGULATION (EC) No 1272/2008)

Chemical name (Concentration)

CAS-No.            Registration                    Classification

number

trifluoroacetic acid (>= 80 % - <= 100 % )

76-05-1            *)

Acute toxicity, Category 4, H332

Skin corrosion, Category 1A, H314

Long-term (chronic) aquatic hazard, Category 3, H412

*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

For the full text of the H-Statements mentioned in this Section, see Section 16.

3.2 Mixture

Not applicable

SECTION 4. First aid measures

4.1 De script ion of first aid measures

General advice

First aider needs to protect himself.

After inhalation: fresh air. Call in physician.

If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.

4.2 Most important symptoms and effects, both acute and  delay ed Irritation and corrosion, Cough, Shortness of breath

Nausea, Vomiting, collapse

Risk of serious damage to eyes.

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SAFETY DATA SHEET

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4.3 Indication of any immediate medical attention and special treatment needed

No information available.

SECTION 5. Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water, Foam, Carbon dioxide (CO2), Dry powder

Unsuitable extinguishing media

For this substance/mixture no limit ations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture Combustible.

Development of hazardous combustion gases or vapours possible in the event of fire.

Fire may cause evolution of:

Hydrogen fluoride

5.3 Advice for firefighters

Special protective equipment for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6. Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

Advice for emergency responders:

Protective equipment see section 8.

6.2 Environmental precautions

Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10).

Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No. 101595). Dispose of properly. Clean up affected area.

6.4 Reference to other sections

Indications about waste treatment see section 13.

Page 4 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

SECTION 7. Handling and storage

7.1 Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Observe label precautions.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

7.2 Conditions for safe storage, including any incompatibilities Requirements for storage areas and containers

No metal containers.

Storage conditions

Tightly closed.

Dry.

Recommended storage temperature see product label.

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.

SECTION 8. Exposure controls/personal protection 8.1 Control parameters

8.2 Exposure controls

Engineering measures

Technical measures and appropriate working operations should be given priority over the use of personal protective equipment.

See section 7.1.

Individual protection measures

Protective clothing needs to be select ed specifically for the workplace, depending on concentrations and quantities of the hazardous substances handled. The chemical resistance of the protective equipment should be enquired at the respective supplier.

Eye/face protection

Tightly fitting safety goggles

Hand protection

full contact:

Page 5 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the related standard EN374, for example KCL 898 Butoject® (full contact), KCL 706 Lapren® (splash contact).

The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374 with samples of the recommended glove types.

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Other protective equipment

Acid-resistant protective clothing

Respiratory protection

required when vapours/aerosols are generated.

Recommended Filter type: Filter B-(P2)

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Environmental exposure controls

Do not let product enter drains.

SECTION 9. Physical and chemical properties

9.1 Information on basic physical and chemical properties

Form

liquid

Colour

colourless

Odour

stinging

Odour Threshold

No information available.

pH

1

at 10 g/l

Melting point

-15 °C

Boiling point/boiling range

72 °C

at 1.013 hPa

Flash point

Method: ISO 2719

not determinable

Page 6 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

SECTION 10. Stability and reactivity

10.1 Reactivity

See section 10.3

10.2 Chemical stability

heat-sensitive

hygroscopic

10.3 Possibility of hazardous reactions

Risk of explosion with:

lithium aluminium hydride, hydrides

Page 7 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Generates dangerous gases or fumes in contact with:

acids

10.4 Conditions to avoid

Strong heating.

Protect from moisture.

10.5 Incompatible materials

rubber, Metals

10.6 Hazardous decomposition products

in the event of fire: See section 5.

SECTION 11. Toxicological information

11.1 Information on toxicological effects

Acute oral toxicity

Symptoms: Nausea, Vomiting, strong pain (risk of perforation!), If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the oesophagus and the stomach.

Acute inhalation toxicity

LC50 Rat: 10 mg/l; 4 h ; vapour

(External MSDS)

Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract, Inhalation may lead to the formation of oedemas in the respiratory tract.

Acute dermal toxicity

This information is not available.

Skin irritation

Rabbit

result : Causes burns.

(External MSDS)

Necrosis Causes poorly healing wounds.

Causes severe burns.

Eye irritation

Causes serious eye damage.

Risk of blindness!

Sensitisation

This information is not available.

Germ cell mutagenicity

Page 8 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

(Lit.)

Carcinogenicity

This information is not available.

Reproductive toxicity

This information is not available.

Teratogenicity

This information is not available.

Specific target organ toxicity - single exposure

This information is not available.

Specific target organ toxicity - repeated exposure

This information is not available.

Aspiration hazard

This information is not available.

11.2 Further information

Systemic effects:

collapse

Damage to:

Kidney

Other dangerous properties can not be excluded.

Handle in accordance with good industrial hygiene and safety practice.

SECTION 12. Ecological information

12.1 Toxicity

Toxicity to fish

static test LC50 Danio rerio (zebra fish): > 999 mg/l; 96 h

Analytical monitoring: yes

OECD Test Guideline 203

Toxicity to daphnia and other aquatic invertebrates

static test EC50 Daphnia magna (Water flea): > 999 mg/l; 48 h

Analytical monitoring: yes

OECD Test Guideline 202

Toxicity to algae

static test ErC50 Anabaena flos-aquae (cyanobacterium): > 1.997 mg/l; 120 h

Analytical monitoring: yes

OECD Test Guideline 201

Toxicity to bacteria

EC50 activated sludge: > 832 mg/l; 3 h

Analytical monitoring: no

OECD Test Guideline 209

Page 9 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity) semi-static test NOEC Daphnia magna (Water flea): > 25 mg/l; 21 d Analytical monitoring: yes

OECD Test Guideline 211

12.2 Persistence and degradability

Biodegradability

11 %; 127 d; aerobic

OECD Test Guideline 301A

Not inherently biodegradable.

12.3 Bioaccumulative potential

Partition coefficient: n-octanol/water

log Pow: -2,1

(External MSDS) Bioaccumulation is not expected.

12.4 Mobility in soil

No information available.

12.5 result s of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.

12.6 Other adverse effects

Additional ecological information

Harmful effect due to pH shift. Caustic even in diluted form. Hazard for drinking water supplies.

Discharge into the environment must be avoided.

SECTION 13. Disposal considerations

Waste treatment methods

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

SECTION 14. Transport information

Inland waterway transport (ADN)

Not relevant

Page 10 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

Not relevant

SECTION 15. Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

Page 11 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out.

SECTION 16. Other information

Full text of H-Statements referred to under sections 2 and 3.

Training advice

Provide adequate information, instruction and training for operators.

Labelling

Hazard pictograms

Signal word

Danger

Hazard statements

H314 Causes severe skin burns and eye damage.

H332 Harmful if inhaled.

H412 Harmful to aquatic life with long lasting effects.

Precautionary statements

Prevention

P273 Avoid release to the environment.

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

Response

P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.

Remove contact lenses, if present and easy to do. Continue rinsing.

P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

Page 12 of 13

The life science business of Merck operates as MilliporeSigma in the US and Canada