Version 8.4 Revision Date 02/02/2021 Print Date 02/04/2021

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1. 1. Product identifiers

Product name              : Heptafluorobutyric acid for synthesis

Product Number            : 8.43443

Catalogue No.              : 843443

Brand                          : Millipore

CAS-No.                      : 375-22-4

1. 2. Relevant identified uses of the substance or mixture and uses advised against

Identified uses              : Chemical for synthesis

1. 3. Details of the supplier of the safety data sheet

Company                    : EMD Millipore Corporation 400 Summit Drive

BURLINGTON MA 01803 UNITED STATES

Telephone                    : +1 800-645-5476

1. 4. Emergency telephone

Emergency Phone #      : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2: Hazards identification

1. 1. Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)

Skin corrosion (Category 1A), H314 Serious eye damage (Category 1), H318

For the full text of the H-Statements mentioned in this Section, see Section 16.

1. 2. GHS Label elements, including precautionary statements

Pictogram

Signal word                      Danger Hazard statement(s)

H314                              Causes severe skin burns and eye damage.

Precautionary statement(s)

P264                              Wash skin thoroughly after handling.

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P280                              Wear protective gloves/ protective clothing/ eye protection/ face protection.

P301 + P330 + P331          IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303 + P361 + P353          IF ON SKIN (or hair): Take off immediately all contaminated

clothing. Rinse skin with water/ shower.

P304 + P340 + P310          IF INHALED: Remove person to fresh air and keep comfortable

for breathing. Immediately call a POISON CENTER/ doctor.

P305 + P351 + P338 + P310

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor.

P363                              Wash contaminated clothing before reuse.

P405                              Store locked up.

P501                              Dispose of contents/ container to an approved waste disposal plant.

1. 3. Hazards not otherwise classified (HNOC) or not covered by GHS - none

SECTION 3: Composition/information on ingredients

3.1    Substances

Formula                      : C4HF7O2

Molecular weight            : 214.04 g/mol

CAS-No.                      : 375-22-4

EC-No.                        : 206-786-3

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

1. 1. De script ion of first-aid measures General advice

First aider needs to protect himself. Show this material safety data sheet to the doctor in

attendance.

If inhaled

After inhalation: fresh air. Call in physician.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.

Millipore - 8.43443                                                                                                                        Page 2 of 8

1. 2. Most important symptoms and effects, both acute and  delay ed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

1. 3. Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

1. 1. Extinguishing media Suitable extinguishing media

Use extinguishing measures that are appropriate to local circumstances and the

surrounding environment.

Unsuitable extinguishing media

For this substance/mixture no limit ations of extinguishing agents are given.

1. 2. Special hazards arising from the substance or mixture

Carbon oxides Hydrogen fluoride Not combustible.

Ambient fire may liberate hazardous vapours. Fire may cause evolution of:

Hydrogen fluoride

1. 3. Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

1. 4. Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

1. 1. Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

1. 2. Environmental precautions

Do not let product enter drains.

1. 3. Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No. 101595). Dispose of properly. Clean up affected area.

1. 4. Reference to other sections

For disposal see section 13.

Millipore - 8.43443                                                                                                                        Page 3 of 8

SECTION 7: Handling and storage

1. 1. Precautions for safe handling

For precautions see section 2.2.

1. 2. Conditions for safe storage, including any incompatibilities Storage conditions

Tightly closed.

Store below +30°C.

Storage class (TRGS 510): 8B: Non-combustible, corrosive hazardous materials

1. 3. Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

1. 1. Control parameters

Ingredients with workplace control parameters

Contains no substances with occupational exposure limit values.

1. 2. Exposure controls

Appropriate engineering controls

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Personal protective equipment Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact Material: Viton®

Minimum layer thickness: 0.7 mm Break through time: 60 min

Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)

Body Protection

Acid-resistant protective clothing

Respiratory protection

required when vapours/aerosols are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Millipore - 8.43443                                                                                                                        Page 4 of 8

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

1. 1. Information on basic physical and chemical properties
      1. Appearance              Form: liquid Color: colorless
      2. Odor                      No data available
      3. Odor Threshold        No data available
      4. pH                          1

1. 1. 5. Melting

point/freezing point

1. 1. 6. Initial boiling point and boiling range

No data available

120 °C 248 °F at 980 hPa

1. 1. 7. Flash point                ()No data available
      8. Evaporation rate        No data available

1. 1. 1. Flammability (solid, gas)

1. 1. 10. Upper/lower flammability or explosive limit s

No data available No data available

1. 1. 11. Vapor pressure        13 hPa at 25 °C (77 °F)

1. 1. 50. Vapor density          7.39 - (Air = 1.0)

1. 1. 1000. Relative density        1.645 g/cm³
      14. Water solubility          No data available

• • • Partition coefficient: n-octanol/water
    • Autoignition temperature
    • Decomposition temperature

No data available No data available No data available

1. 1. 18. Viscosity                  No data available
      19. Explosive properties  No data available
      20. Oxidizing properties    No data available
   2. Other safety information

Relative vapor density

7.39 - (Air = 1.0)

SECTION 10: Stability and reactivity

1. 1. Reactivity

No data available

Millipore - 8.43443                                                                                                                        Page 5 of 8

1. 2. Chemical stability

The product is chemically stable under standard ambient conditions (room temperature).

1. 3. Possibility of hazardous reactions

No data available

1. 4. Conditions to avoid

no information available

1. 5. Incompatible materials

No data available

1. 6. Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

1. 1. Information on toxicological effects Acute toxicity

No data available

Skin corrosion/irritation

Serious eye damage/eye irritation

Causes serious eye damage. Respiratory or skin sensitization Germ cell mutagenicity Carcinogenicity

IARC:      No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP:      No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA:    No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

Specific target organ toxicity - single exposure Specific target organ toxicity - repeated exposure Aspiration hazard

1. 2. Additional Information

Not available

Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea

Millipore - 8.43443                                                                                                                        Page 6 of 8

SECTION 12: Ecological information

1. 1. Toxicity
   2. Persistence and degradability
   3. Bioaccumulative potential
   4. Mobility in soil
   5. result s of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

1. 6. Other adverse effects

SECTION 13: Disposal considerations

13.1 Waste treatment methods Product

Waste material must be disposed of in accordance with the national and loc No mixing

with other waste. Handle uncleaned containers like the product See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

SECTION 14: Transport information DOT (US)

UN number: 3265  Class: 8                  Packing group: II

Proper shipping name: Corrosive liquid, acidic, organic, n.o.s. (heptafluorobutyric acid) Reportable Quantity (RQ):

Poison Inhalation Hazard: No

IMDG

UN number: 3265  Class: 8                  Packing group: II          EMS-No: F-A, S-B Proper shipping name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (heptafluorobutyric acid)

IATA

UN number: 3265  Class: 8                  Packing group: II

Proper shipping name: Corrosive liquid, acidic, organic, n.o.s. (heptafluorobutyric acid)

SECTION 15: Regulatory information SARA 302 Components

This material does not contain any components with a section 302 EHS TPQ.

SARA 313 Components

This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

Massachusetts Right To Know Components

Millipore - 8.43443                                                                                                                        Page 7 of 8