Version 8.3 Revision Date 07/16/2021 Print Date 07/16/2021

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1. 1. Product identifiers

Product name              : Phenolphthalein indicator ACS,Reag. Ph Eur

Product Number            : 1.07233

Catalogue No.              : 107233

Brand                          : Millipore

index -No.                    : 604-076-00-1

CAS-No.                      : 77-09-8

1. 2. Relevant identified uses of the substance or mixture and uses advised against

Identified uses              : Reagent for analysis

1. 3. Details of the supplier of the safety data sheet

Company                    : EMD Millipore Corporation 400 Summit Drive

BURLINGTON MA 01803 UNITED STATES

Telephone                    : +1 800-645-5476

1. 4. Emergency telephone

Emergency Phone #      : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2: Hazards identification

1. 1. Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)

Germ cell mutagenicity (Category 2), H341 Carcinogenicity (Category 1B), H350 Reproductive toxicity (Category 2), H361

Short-term (acute) aquatic hazard (Category 2), H401

For the full text of the H-Statements mentioned in this Section, see Section 16.

1. 2. GHS Label elements, including precautionary statements

Pictogram

Signal word                      Danger Hazard statement(s)

H341                              Suspected of causing genetic defects.

Millipore - 1.07233                                                                                                                        Page 1 of 9

H350                              May cause cancer.

H361                              Suspected of damaging fertility or the unborn child.

H401                              Toxic to aquatic life.

Precautionary statement(s)

P201                              Obtain special instructions before use.

P202                              Do not handle until all safety precautions have been read and understood.

P273                              Avoid release to the environment.

P280                              Wear protective gloves/ protective clothing/ eye protection/ face protection.

P308 + P313                    IF exposed or concerned: Get medical advice/ attention. P405                                      Store locked up.

P501                              Dispose of contents/ container to an approved waste disposal plant.

1. 3. Hazards not otherwise classified (HNOC) or not covered by GHS - none

SECTION 3: Composition/information on ingredients

3.1    Substances

Formula                      : C20H14O4

Molecular weight            : 318.33 g/mol

CAS-No.                      : 77-09-8

EC-No.                        : 201-004-7

index -No.                    : 604-076-00-1

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

1. 1. De script ion of first-aid measures General advice

Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Call in physician.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

Millipore - 1.07233                                                                                                                        Page 2 of 9

If swallowed

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

1. 2. Most important symptoms and effects, both acute and  delay ed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

1. 3. Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

1. 1. Extinguishing media Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limit ations of extinguishing agents are given.

1. 2. Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Development of hazardous combustion gases or vapours possible in the event of fire.

1. 3. Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

1. 4. Further information

Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

1. 1. Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

1. 2. Environmental precautions

Do not let product enter drains.

1. 3. Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.

1. 4. Reference to other sections

For disposal see section 13.

Millipore - 1.07233                                                                                                                        Page 3 of 9

SECTION 7: Handling and storage

1. 1. Precautions for safe handling Advice on safe handling

Work under hood. Do not inhale substance/mixture.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

1. 2. Conditions for safe storage, including any incompatibilities Storage conditions

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible

only to qualified or authorized persons.

Recommended storage temperature see product label.

Storage class (TRGS 510): 6.1D: Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

1. 3. Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

1. 1. Control parameters

Ingredients with workplace control parameters

Contains no substances with occupational exposure limit values.

1. 2. Exposure controls

Appropriate engineering controls

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Personal protective equipment Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0.11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril® L

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please

Millipore - 1.07233                                                                                                                        Page 4 of 9

contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0.11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril® L

Body Protection

protective clothing

Respiratory protection

required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

1. 1. Information on basic physical and chemical properties
      1. Appearance              Form: solid Color: white
      2. Odor                      odorless
      3. Odor Threshold        Not applicable
      4. pH                          No data available

1. 1. 5. Melting

point/freezing point

1. 1. 6. Initial boiling point and boiling range

Melting point: ca.263.7 °C (ca.506.7 °F) at ca.1,013 hPa - OECD Test Guideline 102

> 450 °C > 842 °F at 1,013 hPa - OECD Test Guideline 103

1. 1. 7. Flash point              No data available
      8. Evaporation rate        No data available

1. 1. 1. Flammability (solid, gas)

1. 1. 10. Upper/lower flammability or explosive limit s

The product is not flammable. - Flammability (solids) No data available

1. 1. 11. Vapor pressure        < 0.1 hPa at 50 °C (122 °F) - OECD Test Guideline 104

1. 1. 50. Vapor density          No data available

1. 1. 1000. Density                    1.27 g/cm3 at 32 °C (90 °F)

Relative density        ca.1.29 at 20.6 °C (69.1 °F) - OECD Test Guideline 109

1. 1. 14. Water solubility          0.00336 g/l at 20 °C (68 °F) - OECD Test Guideline 105 -

slightly soluble

• • • Partition coefficient: n-octanol/water

log Pow: 0.9 at 25 °C (77 °F) - OECD Test Guideline 117 - Bioaccumulation is not expected.

Millipore - 1.07233                                                                                                                        Page 5 of 9

1. 1. 16. Autoignition temperature
      17. Decomposition temperature

397 °C (747 °F) - Relative self-ignition temperature for solids No data available

1. 1. 18. Viscosity                  No data available
      19. Explosive properties  No data available
      20. Oxidizing properties    No data available
   2. Other safety information

Bulk density              350 - 450 kg/m3

Surface tension        71.8 mN/m at 3,000g/l at 20 °C (68 °F) - OECD Test Guideline 115

Particle size              56.6 µm - OECD Test Guideline 110 - Mean particle size

SECTION 10: Stability and reactivity

1. 1. Reactivity

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

1. 2. Chemical stability

The product is chemically stable under standard ambient conditions (room temperature).

1. 3. Possibility of hazardous reactions Violent reactions possible with: Strong oxidizing agents

1. 4. Conditions to avoid

no information available

1. 5. Incompatible materials

No data available

1. 6. Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

1. 1. Information on toxicological effects Acute toxicity

Oral: No data available Inhalation: No data available Dermal: No data available

Skin corrosion/irritation

Skin - reconstructed human epidermis (RhE) result : irritating - 42 min

Millipore - 1.07233                                                                                                                        Page 6 of 9

(OECD Test Guideline 439)

Serious eye damage/eye irritation

Eyes - In vitro study result : non-corrosive - 4 h (OECD Test Guideline 437)

Respiratory or skin sensitization Local lymph node assay (LLNA) - Mouse result : Not a skin sensitizer.

(OECD Test Guideline 429)

Germ cell mutagenicity

Suspected of causing genetic defects. Test Type: Ames test

Test system: Salmonella typhimurium

Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471

result : negative

Carcinogenicity

Presumed to have carcinogenic potential for humans

IARC:      2B - Group 2B: Possibly carcinogenic to humans (phenolphthalein)

NTP:      No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA:    No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

Suspected of damaging fertility.

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

1. 2. Additional Information

Repeated dose toxicity - Rat - male and female - Oral - 13 Weeks - NOAEL (No observed adverse effect level) - 800 mg/kg

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

After uptake of large quantities:

Nausea Vomiting

Gastrointestinal disturbance Fever

cardiovascular disorders CNS disorders

The substance has a laxative effect.

Millipore - 1.07233                                                                                                                        Page 7 of 9

Other dangerous properties can not be excluded.

This substance should be handled with particular care. Stomach - Irregularities - Based on Human Evidence

SECTION 12: Ecological information

1. 1. Toxicity

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h (OECD Test Guideline 202)

Toxicity to algae        static test ErC50 - Desmodesmus subspicatus (green algae) - > 3.33 mg/l - 72 h

(OECD Test Guideline 201)

static test NOEC - Desmodesmus subspicatus (green algae) - 0.57 mg/l - 72 h

(OECD Test Guideline 201)

1. 2. Persistence and degradability

Biodegradability        aerobic - Exposure time 28 d

result : 76 % - Readily biodegradable. (OECD Test Guideline 301F)

Remarks: The 10 day time window criterion is not fulfilled.

1. 3. Bioaccumulative potential

No data available

1. 4. Mobility in soil

No data available

1. 5. result s of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

1. 6. Other adverse effects

No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods Product

Waste material must be disposed of in accordance with the national and local regulations.

Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself. See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Millipore - 1.07233                                                                                                                        Page 8 of 9

SECTION 14: Transport information

DOT (US)

Not dangerous goods

IMDG

Not dangerous goods

IATA

Not dangerous goods

Further information

Not classified as dangerous in the meaning of transport regulations.

SECTION 15: Regulatory information SARA 302 Components

This material does not contain any components with a section 302 EHS TPQ.

SARA 313 Components

The following components are subject to reporting levels established by SARA Title III, Section 313:

phenolphthalein

CAS-No. 77-09-8

Revision Date 2020-07-14